Tinospora cordifolia, which is known by the common names heart-leaved moonseed, guduchi and giloy, is an herbaceous vine of the family Menispermaceae indigenous to the tropical areas of India, Myanmar and Sri Lanka.
1200 m and lower altitude. It grows in hot, slightly humid forests, and leaning against walls. It is a climber.
Antioxidant activity – inhibits lipid peroxidation; reduces oxidative stress; scavenge free radicals; has neuro-protective effect.
Adaptogenic activity – increases resistance of the body to physical, chemical and biological stress and builds energy and general vitality; improves physical performance of healthy individuals in the presence of physical stress; suppresses over-activation of sympathetic nervous system; improves cognitive function in sleep deprived conditions.
Anti-stress activity – normalizes stress-induced biochemical changes in norepinephrine, dopamine and serotonin.
Antidepressant activity – possibly via inhibition of monoamine oxidase activity.
Cognitive function improvement – protects brain from ischemic damage; exhibits acetylcholinesterase inhibitory activity; prevents oxidative stress.
Aphrodisiac activity – improve libido and potency.
Radioprotective and cytoprotective activity.
Anti-neoplastic activity – shows to reduce tumour mass and increase survival time; exhibits regulatory effect on serum cytokines; pretreatment showed protective effect on spleen and testis; HeLa cells showed increased radiosensitivity; shows apparent cytotoxic activity against tumour cells and induces cell apoptosis.
Anti-bacterial activity – shows broad spectrum inhibitory activity; shows to inhibit the survival of Mycobacterium tuberculosis in macrophages.
Analgesic activity – antioxidant and calcium action contribute for attenuating sciatica pain; it increases levels of monoamines like noradrenaline, serotonin and dopamine which may be responsible for its anti-nociceptive activity; it contains alkaloids, glycosides and flavonoids which inhibit production of prostaglandins. Analgesic activity shows to involve both central (opioid receptors) as well as peripheral (inhibition of PG synthesis) mechanisms.
Hepatoprotective action – normalizes altered liver functions; regulates carbohydrate and lipid metabolism; protects liver from lead induced damage.
Cardioprotective action – exhibits reduction in infarct size and in serum and heart lipid peroxide levels; showed to normalize atrial and ventricular fibrillation and flutter; acts as anti-arrhythmic; decreases heart rate.
Gastroprotective action – relieves nonspecific diarrhoea, dysentery, peptic ulcer and abdominal pain.
Neuro-protective action – increases dopamine levels; reduces dopaminergic neurodegeneration; reduces iron induced neural damage; protects from oxidative stress; suggests positive impact on preventing development of Parkinson’s disease.
Hypolipidemic activity – reduces serum and tissue cholesterol, phospholipids and free fatty acid levels.
Anti-coagulant and platelet anti-aggregators activity
Immunomodulatory activity – regulates serum cytokines; has anti-complement effect; reduces allergic rhinitis, sneezing, nasal obstruction and pruritis.
Anti-diabetic activity – reduces blood glucose levels; improves lipid profile; reduces oxidative stress; prevents retinal oxidative stress and restores antioxidant enzyme levels; demonstrates improvement in the pain relief, motor and sensory nerve conduction velocities in patients with neuropathy; attenuates progression of renal damage and prevents polyuria; helps healing of diabetic ulcers; protects against ischemic and glucose deprived brain damage in chronic diabetes. Shows to be effective in preventing, postponing or treatment of secondary diabetic complications.
Role in gestational diabetes – provides significant protection against diabetes-induced maternal and fatal oxidative stress.
Urogenital system effect – shows to reduce prostate size; decreases blood urea concentration in uraemia; relieves urinary infections and dissolves urinary calculi.
Osteoprotective effect – stimulates growth of osteoblasts; increases differentiation of cells into osteoblastic lineage; increases mineralization of bone-like matrix; prevents bone loss; provides nutritional calcium; shows antiporotic effect.
Nutritional supplementation – provide sufficient amount of protein, fibre, major and minor elements. It has high potassium (regulatory function of nerve impulses), high chromium (regulation of carbohydrate utilization), sufficient iron (hematinic) and calcium (regulatory functions in nervous, cardiovascular and musculoskeletal systems).
Balances mixed disorders of Wind, Bile and Phlegm
Balances Wind and blood combined disorders
Balances blood sugar levels
Increases body strength
Improves metabolic activities
Strengthens the eyes
Strengthens the lungs
Increase digestive heat
Stops diarrhoea and dysentery
Stops vomiting and nausea
Relieves belching, bloating, flatulence and abdominal pain
Heals mouth ulcers
Relieves thirst and dryness
Immune system and detoxification:
Prevents upper and lower respiratory tract infections
Treats cold and flu disorders
Relieves pharyngitis, tonsilitis
Clears lung inflammation
Purifies blood and lymph
Relieves joint swelling, redness and pain
Relieves gout, arthritis and rheumatoid arthritis
Relieves rigidity of muscles
Has analgesic property
Acts as immunostimulant
Clears parasites, bacteria and viruses
Clears heat and dampness
- Tinospora cordifolia uses, benefits and dosage
- Antidiabetic claims of Tinospora cordifolia (Willd.) Miers: critical appraisal and role in therapy / Asian Pacific Journal of Tropical Biomedicine
- Genus Tinospora: Ethnopharmacology, Phytochemistry, and Pharmacology
- Effect of Tinospora cordifolia on physical and cardiovascular performance induced by physical stress in healthy human volunteers
- Tinospora cordifolia ameliorates anxiety-like behavior and improves cognitive functions in acute sleep deprived rats
- The Analgesic, Anti-Inflammatory and Anti-Pyretic Activities of Tinospora cordifolia
- Clinical Evaluation of Analgesic Activity of Guduchi (Tinospora Cordifolia) Using Animal Model
- Neuroprotective effect of Tinospora cordifolia ethanol extract on 6-hydroxy dopamine induced Parkinsonism
- Protective Role of Tinospora cordifolia against Lead-induced Hepatotoxicity
- Cardioprotective activity of alcoholic extract of Tinospora cordifolia (Willd.) Miers in calcium chloride-induced cardiac arrhythmia in rats
- Evidences for the Involvement of Monoaminergic and GABAergic Systems in Antidepressant-like Activity of Tinospora cordifolia in Mice