Valued for its medicinal properties since ancient times. Pomegranate seeds owe their superfood status to polyphenols, powerful antioxidants thought to offer heart health and anti-cancer benefits. In fact, pomegranate seeds have more antioxidant power than cranberry juice or green tea.
Dried seed and fruit
Anti-diarrhoeal activity– exhibits intestinal anti-secretory activity.
Anti-ulcer activity – significantly decreases gastric lesions.
Anti-hyperlipidemic activity – surpasses triglyceride synthesis in liver through inhibition of fatty acid synthase; reduces serum triglyceride, total cholesterol and LDL levels; decreases cholesterol absorption and affects HMG-CoA reductase.
Anti-obesity effect – shows to cause decrease in body weight and improve serum lipid profile.
Anti-diabetic effect – mildly reduces plasma glucose levels; increases tissue sensitivity towards insulin; inhibits diabetes-induced inflammatory processes; improves lipid profile.
Nephroprotective effect – produces vasodilation and increases blood flow in kidneys; reduces oxidative stress.
Effect on preeclampsia – shows protective effect on endothelial cells of preeclamptic patients.
Hepatoprotective effect – due to its antioxidant and anti-inflammatory effects as well as inhibition of collagen synthesis, shows to protect against liver fibrosis.
Ergogenic effect – shows to enhance vessel diameter, blood flow and delay fatigue during exercises.
Anti-atherosclerotic effect – protects endothelial function, improves lipid profile.
Anti-hypertensive effect – inhibits serum angiotensin converting enzyme (ACE) and decreases systolic blood pressure.
Cardioprotective effect – prevents cardiac damage; reduces myocardial ischemia and improves myocardial perfusion; shows significant therapeutic value in prophylactic treatment of myocardial infarction.
Anti-microbial activity – shows antibacterial activity (against Proteus spp., H.influenza, Klebsiella pneumoniae, Pseudomonas aeruginosa, Streptococcus spp., Staphylococcus aureus, Enterocuccus faecalis, E.coli); anti-fungal activity (Candida albicans, Trichophyton spp.); antiviral activity (against genital herpes virus, Herpes simplex virus, hepatitis B virus, hepatitis C virus); anti-parasitic activity (Taenia spp., Ascaris lumbricoides); shows to inhibit oral pathogens.
Anti-inflammatory activity – reduces levels of pro-inflammatory cytokines; inhibits COX, LOX.
Anti-acne activity – inhibits growth of acne-related bacteria; down-regulates sebum production by reducing lipase activity; attenuates the inflammatory status; prevents keratinocyte over-proliferation.
Anti-osteoporotic effect – shows to promote bone cell proliferation and differentiation in primary osteoblasts; inhibits bone resorption process.
Anti-rheumatoid arthritis effect – exhibits anti-inflammatory effect; prevents development of joint damage; prevents maintenance and development of inflammation in RA; reduces severity and incidence of joint inflammation; inhibits cartilage degradation; helps to maintain joint integrity and function.
Antioxidant activity – inhibits lipid peroxidation; protects from oxidative stress; has free radical scavenging activity.
Neuroprotective activity – inhibits cholinesterase activity; prevents accumulation of lipid in brain; protects brain from stress oxidant; protects against cerebral ischemia-reperfusion induced oxidative brain injury; inhibits learning and memory deficits and neuronal cell death caused by amyloid-beta-induced oxidative stress; thus may be beneficial for prevention, management and supportive treatment of neurodegenerative diseases; shows to reduce neuropathic pain in acquired peripheral neuropathy.
Anti-cancer activity – shows to be chemopreventive/ chemotherapeutic agent; exhibits anti-inflammatory, anti-proliferative and anti-tumorigenic effects on skin, breast, prostate, lung and colon cancers.